Difference between revisions of "The use of DMSO"
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Revision as of 12:51, 23 March 2022
I was wondering if any of you have first-hand experience (and / or are aware of recognised guidance) of using DMSO (Dimethyl sulfoxide) to facilitate moving substances into solution for subsequent injection into mice via the S/C route, from a toxicity perspective? Upon literature review I have come across some varying statements / information on this, both for total quantity as well as % solution of DMSO (v/v) and wondered if anyone had experience of this to help me please?
This is a very thorough guide to vehicles: https://www.gadconsulting.com/wp-content/uploads/2016/02/gad-vehicles-database.pdf
Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects.