Difference between revisions of "Intraperitoneal injection"

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(Added Gjendal reference)
 
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Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. [[User:AS191219|AS191219]] ([[User talk:AS191219|talk]]) 08:33, 18 March 2020 (UTC)
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Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. [[User:AS191219|AS191219]] ([[User talk:AS191219|talk]]) 08:33, 18 March 2020 (UTC)  
  
 
The BVAAWF/FRAME/RSPCA/UFAW joint working group's report<ref>{{Cite web|url=https://journals.sagepub.com/doi/abs/10.1258/0023677011911345|title=Refining procedures for the administration of substances|last=|first=|date=|website=|url-status=live|archive-url=|archive-date=|access-date=|df=dmy-all}}</ref> on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.
 
The BVAAWF/FRAME/RSPCA/UFAW joint working group's report<ref>{{Cite web|url=https://journals.sagepub.com/doi/abs/10.1258/0023677011911345|title=Refining procedures for the administration of substances|last=|first=|date=|website=|url-status=live|archive-url=|archive-date=|access-date=|df=dmy-all}}</ref> on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.
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*Zatroch ''et al.'' (2019): [https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0982-y Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (''Rattus norvegicus'')]
 
*Zatroch ''et al.'' (2019): [https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0982-y Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (''Rattus norvegicus'')]
 
*Reimer ''et al''. (2019): [https://www.biorxiv.org/content/biorxiv/early/2019/07/15/703173.full.pdf Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.]
 
*Reimer ''et al''. (2019): [https://www.biorxiv.org/content/biorxiv/early/2019/07/15/703173.full.pdf Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.]
*[[Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections (Gjendal et al., 2019)|Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections]] (Gjendal ''et al''., 2019)
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*Gjendal ''et al''. (2019): [https://www.sciencedirect.com/science/article/abs/pii/S0031938418309521 Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections]
 
*Turner ''et al''. (2011): [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/ Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider]
 
*Turner ''et al''. (2011): [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/ Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider]
 
*Ballard (2009): [https://www.cabdirect.org/cabdirect/abstract/20093178358 Intraperitoneal route of administration: how accurate is this technique?]
 
*Ballard (2009): [https://www.cabdirect.org/cabdirect/abstract/20093178358 Intraperitoneal route of administration: how accurate is this technique?]

Latest revision as of 22:15, 31 January 2021

Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. AS191219 (talk) 08:33, 18 March 2020 (UTC)

The BVAAWF/FRAME/RSPCA/UFAW joint working group's report[1] on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.

See also guidance on severity classification of injection techniques.

Other literature


References

  1. "Refining procedures for the administration of substances".