Difference between revisions of "The use of DMSO"
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Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects. | Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects. | ||
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| + | See also [https://pubmed.ncbi.nlm.nih.gov/23383426 Williams ''et al.'' (2013): Strategies to address low drug solubility in discovery and development]. | ||
Latest revision as of 11:54, 9 March 2023
The text on this page is taken from an informal compilation of opinions of contributors to the online VOLE List. As such, they are not peer reviewed and may contain differences of opinion. Those wishing to contact the list may contact Adrian Smith.
I was wondering if any of you have first-hand experience (and / or are aware of recognised guidance) of using DMSO (Dimethyl sulfoxide) to facilitate moving substances into solution for subsequent injection into mice via the S/C route, from a toxicity perspective? Upon literature review I have come across some varying statements / information on this, both for total quantity as well as % solution of DMSO (v/v) and wondered if anyone had experience of this to help me please?
This is a very thorough guide to vehicles: https://www.gadconsulting.com/wp-content/uploads/2016/02/gad-vehicles-database.pdf
Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects.
See also Williams et al. (2013): Strategies to address low drug solubility in discovery and development.
