Tail vein injection
Tail vein injection in black mice can be quite difficult. To improve the contrast of the veins and their visibility, a special 180° LED illumintaion device can applied. In addition, it was reported that a Broome style restrainer and effortless insulin syringes for i.v. injection can facilitate intravenous injection. More information on this refinement strategy can be found here.
Expert for this refinemt technique: Juerg Messer, Roche, Basel, Switzerland