Detection of pain and distress in mice
Miranda Gallo et al. describe the development of TINT (Time to Incorporate to Nest Test), a binary measure of the presence or absence of nesting behaviour, as a species-specific method of identifying moderate to severe pain and distress in mice. They compared TINT with other variables such as weight loss, food consumption, and scores derived from the Mouse Grimace Scale.
- Gallo, Miranda S; Karas, Alicia Z; Pritchett-Corning, K; Garner Guy Mulder, JP; Gaskill, BN. "Tell-tale TINT: Does the Time to Incorporate into Nest Test Evaluate Postsurgical Pain or Welfare in Mice?". Journal of the American Association for Laboratory Animal Science. 59 (1): 37–45.