Difference between revisions of "Refinement of oral gavage"
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(Created page with "Oral gavage can be stressful to laboratory animals. There are several refinement options and alternatives to oral gavage. Their suitability in a specific experiment has to be...") |
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=== Examples for alternatives to oral gavage (voluntary drug intake) === | === Examples for alternatives to oral gavage (voluntary drug intake) === | ||
| − | When possible drugs can be mixed with palatble food that is ingested voluntary by the animals. There are several examples described in the literature, including the voluntary intake of analgesics via nutella. | + | When possible drugs can be mixed with palatble food that is ingested voluntary by the animals. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also [[analgesia]]). |
* [https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey] | * [https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey] | ||
* Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam] | * Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam] | ||
* Micropipette Drug Administration ([https://www.sciencedirect.com/science/article/pii/S0889159120302543 MDA]) with condensed milk | * Micropipette Drug Administration ([https://www.sciencedirect.com/science/article/pii/S0889159120302543 MDA]) with condensed milk | ||
Revision as of 10:05, 17 March 2022
Oral gavage can be stressful to laboratory animals. There are several refinement options and alternatives to oral gavage. Their suitability in a specific experiment has to be checked carefully.
Refinement examples for rodents
- Sugar coating gavage needles
- Use of anesthesia
- Habituation / training
Examples for alternatives to oral gavage (voluntary drug intake)
When possible drugs can be mixed with palatble food that is ingested voluntary by the animals. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also analgesia).
- Honey
- Jam, e.g. strawberry jam
- Micropipette Drug Administration (MDA) with condensed milk
