Difference between revisions of "Refinement of oral gavage"
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Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully. | Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully. | ||
| − | === Refinement examples for rodents === | + | ===Refinement examples for rodents=== |
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| − | === Examples for alternatives to oral gavage (voluntary drug intake) === | + | *"Sugar coating" gavage needles, e.g. using sweet solutions that support the swallowing of the gavage needle/tube |
| + | *Habituation / training | ||
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| + | ===Examples for alternatives to oral gavage (voluntary drug intake)=== | ||
Some drugs por substances can be mixed with palatble food or fluids that are ingested voluntary by the animals. In many cases the voluntary oral intake of drugs resembles the situation in human patients better. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also [[analgesia]]). | Some drugs por substances can be mixed with palatble food or fluids that are ingested voluntary by the animals. In many cases the voluntary oral intake of drugs resembles the situation in human patients better. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also [[analgesia]]). | ||
| − | * [https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey] | + | |
| − | * Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam] | + | *[https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey] |
| − | * Micropipette Drug Administration ([https://www.sciencedirect.com/science/article/pii/S0889159120302543 MDA]) with condensed milk | + | *Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam] |
| + | *Micropipette Drug Administration ([https://www.sciencedirect.com/science/article/pii/S0889159120302543 MDA]) with condensed milk | ||
Revision as of 12:31, 17 March 2022
Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully.
Refinement examples for rodents
- "Sugar coating" gavage needles, e.g. using sweet solutions that support the swallowing of the gavage needle/tube
- Habituation / training
Examples for alternatives to oral gavage (voluntary drug intake)
Some drugs por substances can be mixed with palatble food or fluids that are ingested voluntary by the animals. In many cases the voluntary oral intake of drugs resembles the situation in human patients better. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also analgesia).
- Honey
- Jam, e.g. strawberry jam
- Micropipette Drug Administration (MDA) with condensed milk
