The use of DMSO - Revision history

Adriansmith: additional reference

2023-03-09T11:54:32Z

additional reference

AS191219 at 12:52, 23 March 2022

2022-03-23T12:52:03Z

AS191219: Created page

2022-03-23T12:51:30Z

Created page

New page

'''I was wondering if any of you have first-hand experience (and / or are aware of recognised guidance) of using DMSO (Dimethyl sulfoxide) to facilitate moving substances into solution for subsequent injection into mice via the S/C route, from a toxicity perspective? Upon literature review I have come across some varying statements / information on this, both for total quantity as well as % solution of DMSO (v/v) and wondered if anyone had experience of this to help me please?'''

This is a very thorough guide to vehicles: https://www.gadconsulting.com/wp-content/uploads/2016/02/gad-vehicles-database.pdf

Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects.

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	Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects.		Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects.
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		+	See also [https://pubmed.ncbi.nlm.nih.gov/23383426 Williams ''et al.'' (2013): Strategies to address low drug solubility in discovery and development].

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	+	''The text on this page is taken from an informal compilation of opinions of contributors to the online VOLE List. As such, they are not peer reviewed and may contain differences of opinion. Those wishing to contact the list may contact [[Adrian Smith]].''