Refinement of oral gavage - Revision history

Adriansmith: added link to MDA page

2024-05-13T10:39:36Z

added link to MDA page

PJ191219: added picture

2024-04-22T11:43:43Z

added picture

PJ191219 at 12:59, 17 April 2024

2024-04-17T12:59:03Z

PJ191219 at 12:56, 17 April 2024

2024-04-17T12:56:33Z

PJ191219 at 12:53, 17 April 2024

2024-04-17T12:53:55Z

PJ191219: added more detail

2024-04-17T12:39:44Z

added more detail

PJ191219 at 12:32, 17 March 2022

2022-03-17T12:32:29Z

PJ191219 at 12:31, 17 March 2022

2022-03-17T12:31:56Z

PJ191219 at 12:31, 17 March 2022

2022-03-17T12:31:24Z

PJ191219 at 10:05, 17 March 2022

2022-03-17T10:05:49Z

@@ Line 1: / Line 1: @@
 [[File:MDAvsOG.jpg|alt=There are several alternatives to oral gavage in rodents, for example micropipette-guided drug administration (MDA).|thumb|There are several alternatives to oral gavage (left) in rodents, for example micropipette-guided drug administration (MDA, right). Picture by Rodent MDA Consortium 2024.]]
 Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully.
 ===Refinement examples for rodents===

← Older revision		Revision as of 11:43, 22 April 2024
Line 1:		Line 1:
		+	[[File:MDAvsOG.jpg\|alt=There are several alternatives to oral gavage in rodents, for example micropipette-guided drug administration (MDA).\|thumb\|There are several alternatives to oral gavage (left) in rodents, for example micropipette-guided drug administration (MDA, right). Picture by Rodent MDA Consortium 2024.]]
	Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully.		Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully.

@@ Line 14: / Line 14: @@
 *Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam]
 *Jellies
-*[[Micropipette Drug Administration (MDA)]] Method with diluted condensed milk
+*[[MDA (micropipette-guided drug administration) Method]] with diluted condensed milk
 **for '''mice''' see for example [https://www.nature.com/articles/s41684-021-00723-0 Schalbetter et al.] or [https://www.sciencedirect.com/science/article/pii/S0889159120302543 Scarborough et al]. for '''rats''' [https://www.sciencedirect.com/science/article/pii/S016502702300170X Heraudeau et al].

@@ Line 14: / Line 14: @@
 *Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam]
 *Jellies
-*[[Micropipette Drug Administration (MDA)]] with diluted condensed milk
+*[[Micropipette Drug Administration (MDA)]] Method with diluted condensed milk
 **for '''mice''' see for example [https://www.nature.com/articles/s41684-021-00723-0 Schalbetter et al.] or [https://www.sciencedirect.com/science/article/pii/S0889159120302543 Scarborough et al]. for '''rats''' [https://www.sciencedirect.com/science/article/pii/S016502702300170X Heraudeau et al].

@@ Line 14: / Line 14: @@
 *Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam]
 *Jellies
-*Micropipette Drug Administration (MDA) with diluted condensed milk
+*[[Micropipette Drug Administration (MDA)]] with diluted condensed milk
 **for '''mice''' see for example [https://www.nature.com/articles/s41684-021-00723-0 Schalbetter et al.] or [https://www.sciencedirect.com/science/article/pii/S0889159120302543 Scarborough et al]. for '''rats''' [https://www.sciencedirect.com/science/article/pii/S016502702300170X Heraudeau et al].

@@ Line 6: / Line 6: @@
 *Habituation / training
-===Examples for alternatives to oral gavage (voluntary drug intake)===
+===Examples for alternatives to oral gavage (voluntary oral drug intake)===
-Some drugs or substances can be mixed with palatable food or fluids that are ingested voluntary by the animals. In many cases the voluntary oral intake of drugs resembles the situation in human patients better. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also [[analgesia]]).
+Some drugs or substances can be mixed with palatable food or fluids that are ingested voluntary by the animals. In many cases the voluntary oral intake of drugs resembles the situation in human patients better. There are several examples described in the literature or shared by experts (see also [[analgesia]]):
 *[https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey]
 *Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam]
-*Micropipette Drug Administration ([https://www.sciencedirect.com/science/article/pii/S0889159120302543 MDA]) with condensed milk
+*Jellies

@@ Line 1: / Line 1: @@
 Oral gavage is an important drug administration technique that requires training to be performed competent. Even if performed competently and carefully, oral gavage can be stressful to laboratory animals and carries the risk of injury. There are several refinement options and alternatives to oral gavage available. The suitability of these refinements should be considered for each specific experiment carefully.
-=== Refinement examples for rodents ===
+===Refinement examples for rodents===
-=== Examples for alternatives to oral gavage (voluntary drug intake) ===
+*"Sugar coating" gavage needles, e.g. using sweet solutions that support the swallowing of the gavage needle/tube
 Some drugs por substances can be mixed with palatble food or fluids that are ingested voluntary by the animals. In many cases the voluntary oral intake of drugs resembles the situation in human patients better. There are several examples described in the literature, including the voluntary intake of analgesics via nutella (see also [[analgesia]]).
 * [https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey]
-* Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam]
+*[https://www.ingentaconnect.com/content/aalas/jaalas/2012/00000051/00000002/art00011 Honey]
-* Micropipette Drug Administration ([https://www.sciencedirect.com/science/article/pii/S0889159120302543 MDA]) with condensed milk
+*Jam, e.g. [https://journals.sagepub.com/doi/full/10.1177/0023677220950782 strawberry jam]