Intraperitoneal injection - Revision history

Werenskjold at 22:15, 31 January 2021

2021-01-31T22:15:30Z

AS191219 at 12:23, 11 November 2020

2020-11-11T12:23:03Z

AS191219 at 12:22, 11 November 2020

2020-11-11T12:22:01Z

AS191219: Added Gjendal reference

2020-11-11T12:20:46Z

Added Gjendal reference

AS191219 at 12:19, 11 November 2020

2020-11-11T12:19:48Z

AS191219 at 15:13, 26 October 2020

2020-10-26T15:13:04Z

AS191219: Created page with "Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This..."

2020-10-26T15:09:35Z

Created page with "Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This..."

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Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. AS191219 (talk) 08:33, 18 March 2020 (UTC)
The BVAAWF/FRAME/RSPCA/UFAW joint working group's report on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.
See also guidance on severity classification of injection techniques.
Other literature
Intraperitoneal Drug Administration (In Neglected Factors in Pharmacology and Neuroscience Research, Ed. V. Claassen)
University of Wollongong Animal Ethics Committee (2019): Position Statement on Intraperitoneal Injections in Rabbits
Al Shoyaib et al. (2019): Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?
Coria-Avila et al. (2017): Cecum location in rats and the implications for intraperitoneal injections
Wokke (2017): Refinement: Evaluating stress and accuracy of different intraperitoneal techniques in mice
Zatroch et al. (2019): Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus)
Reimer et al. (2019): Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.
Turner et al. (2011): Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider
Ballard (2009): Intraperitoneal route of administration: how accurate is this technique?
Coria-Avila et al. (2007) Cecum location in rats and the implications for intraperitoneal injections
Gaines Das & North (2007): Implications of experimental technique for analysis and interpretation of data from animal experiments: outliers and increased variability resulting from failure of intraperitoneal injection procedures
Svendsen (2005): Ethics and Animal Welfare Related to in vivo Pharmacology and Toxicology in Laboratory Animals
Ravanel (1933): The hazards of intraperiteonal injections
Guarnieri (2016): Considering the risks and safety of intraperitoneal injections
Davis et al. (2014): Behavioral, clinical and pathological effects of multiple daily intraperitoneal injections on female mice
Procedures with Care: Intraperiteonal injection in the mouse
Lewis et al. (1966): Error of intraperiteonal injections in rats
Wokke (2017): Refinement: Evaluating stress and accuracy of different intraperitoneal injection techniques in mice

References
"Refining procedures for the administration of substances".

← Older revision		Revision as of 22:15, 31 January 2021
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−	Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. [[User:AS191219\|AS191219]] ([[User talk:AS191219\|talk]]) 08:33, 18 March 2020 (UTC)	+	Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. [[User:AS191219\|AS191219]] ([[User talk:AS191219\|talk]]) 08:33, 18 March 2020 (UTC)

	The BVAAWF/FRAME/RSPCA/UFAW joint working group's report<ref>{{Cite web\|url=https://journals.sagepub.com/doi/abs/10.1258/0023677011911345\|title=Refining procedures for the administration of substances\|last=\|first=\|date=\|website=\|url-status=live\|archive-url=\|archive-date=\|access-date=\|df=dmy-all}}</ref> on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.		The BVAAWF/FRAME/RSPCA/UFAW joint working group's report<ref>{{Cite web\|url=https://journals.sagepub.com/doi/abs/10.1258/0023677011911345\|title=Refining procedures for the administration of substances\|last=\|first=\|date=\|website=\|url-status=live\|archive-url=\|archive-date=\|access-date=\|df=dmy-all}}</ref> on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.

@@ Line 14: / Line 14: @@
 *Zatroch ''et al.'' (2019): [https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0982-y Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (''Rattus norvegicus'')]
 *Reimer ''et al''. (2019): [https://www.biorxiv.org/content/biorxiv/early/2019/07/15/703173.full.pdf Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.]
-*[https://www.sciencedirect.com/science/article/abs/pii/S0031938418309521 Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections] (Gjendal ''et al''., 2019)
+*Gjendal ''et al''. (2019): [https://www.sciencedirect.com/science/article/abs/pii/S0031938418309521 Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections]
 *Turner ''et al''. (2011): [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/ Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider]
 *Ballard (2009): [https://www.cabdirect.org/cabdirect/abstract/20093178358 Intraperitoneal route of administration: how accurate is this technique?]

@@ Line 14: / Line 14: @@
 *Zatroch ''et al.'' (2019): [https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0982-y Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (''Rattus norvegicus'')]
 *Reimer ''et al''. (2019): [https://www.biorxiv.org/content/biorxiv/early/2019/07/15/703173.full.pdf Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.]
-*[[Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections (Gjendal et al., 2019)|Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections]] (Gjendal ''et al''., 2019)
+*[https://www.sciencedirect.com/science/article/abs/pii/S0031938418309521 Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections] (Gjendal ''et al''., 2019)
 *Turner ''et al''. (2011): [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/ Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider]
 *Ballard (2009): [https://www.cabdirect.org/cabdirect/abstract/20093178358 Intraperitoneal route of administration: how accurate is this technique?]

@@ Line 14: / Line 14: @@
 *Zatroch ''et al.'' (2019): [https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0982-y Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (''Rattus norvegicus'')]
 *Reimer ''et al''. (2019): [https://www.biorxiv.org/content/biorxiv/early/2019/07/15/703173.full.pdf Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.]
-*Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections (Gjendal et al., 2019)
+*[[Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections (Gjendal et al., 2019)|Burrowing and nest building activity in mice after exposure to grid floor, isofluorane or ip injections]] (Gjendal ''et al''., 2019)
 *Turner ''et al''. (2011): [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/ Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider]
 *Ballard (2009): [https://www.cabdirect.org/cabdirect/abstract/20093178358 Intraperitoneal route of administration: how accurate is this technique?]

@@ Line 14: / Line 14: @@
 *Zatroch ''et al.'' (2019): [https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0982-y Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (''Rattus norvegicus'')]
 *Reimer ''et al''. (2019): [https://www.biorxiv.org/content/biorxiv/early/2019/07/15/703173.full.pdf Intraperitoneal injection of sodium pentobarbital is associated with pain in rats.]
 *Turner ''et al''. (2011): [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/ Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider]
 *Ballard (2009): [https://www.cabdirect.org/cabdirect/abstract/20093178358 Intraperitoneal route of administration: how accurate is this technique?]

@@ Line 1: / Line 1: @@
-Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. AS191219 (talk) 08:33, 18 March 2020 (UTC)
+Intraperitoneal injection (i.p.) is commonly used in laboratory animals, largely because the technique is apparently easy to perform compared to other parenteral methods. This is in contrast to human medicine. The technique has a number of potential weaknesses which need to be addressed. The purpose of this wikipage is to collect information about scientific studies of the technique, as well as relevant user experience. [[User:AS191219|AS191219]] ([[User talk:AS191219|talk]]) 08:33, 18 March 2020 (UTC)
 The BVAAWF/FRAME/RSPCA/UFAW joint working group's report on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.
-See also guidance on severity classification of injection techniques.
+The BVAAWF/FRAME/RSPCA/UFAW joint working group's report<ref>{{Cite web|url=https://journals.sagepub.com/doi/abs/10.1258/0023677011911345|title=Refining procedures for the administration of substances|last=|first=|date=|website=|url-status=live|archive-url=|archive-date=|access-date=|df=dmy-all}}</ref> on refinement of procedures for substance administration cites a number of limitations and potential problems with the technique. They conclude that this route should not be used routinely (except for administration of certain anaesthetics) as other routes are conveniently accessible and usually preferred for research purposes. The technique is not recommended for animals larger than rodents, nor for pregnant animals since the needle can puncture the gravid uterus. They state that the technique should never be used with birds because the substance may go into the air sacs. Substances which are irritant can be life threatening when administered by this route. There can be appreciable reaction in the peritoneal cavity including pain, formation of fibrous tissue and adhesions. The report contains references on the subject.
 Other literature
-References
+*[https://www.sciencedirect.com/science/article/pii/B9780444818713500102 Intraperitoneal Drug Administration] (In Neglected Factors in Pharmacology and Neuroscience Research, Ed. V. Claassen)
-"Refining procedures for the administration of substances".
+*University of Wollongong Animal Ethics Committee (2019): [https://documents.uow.edu.au/content/groups/public/@web/@raid/documents/doc/uow262163.pdf Position Statement on Intraperitoneal Injections in Rabbits]