The use of DMSO

The text on this page is taken from an informal compilation of opinions of contributors to the online VOLE List. As such, they are not peer reviewed and may contain differences of opinion. Those wishing to contact the list may contact Adrian Smith.

I was  wondering if any of you have first-hand experience (and / or are aware of recognised guidance) of using DMSO (Dimethyl sulfoxide) to facilitate moving substances into solution for subsequent injection into mice via the S/C route, from a toxicity perspective? Upon literature review I have come across some varying statements / information on this, both for total quantity as well as % solution of DMSO (v/v) and wondered if anyone had experience of this to help me please?

This is a very thorough guide to vehicles: https://www.gadconsulting.com/wp-content/uploads/2016/02/gad-vehicles-database.pdf

Generally DMSO is used at 5-10% (often with other components such as cremaphor) with no adverse effects.